Researchers have solved the three-dimensional structure of a protein complex involved in vertebrate vision at atomic resolution
Researchers have solved the three-dimensional structure of a protein complex involved in vertebrate vision at atomic resolution, a finding that has broad implications for our understanding of biological signaling processes and the design of over a third of the drugs on the market today. The findings illuminate how signals from photons (particles of light) get amplified in the eye. More importantly, the study provides insights into how the largest family of cell membrane proteins -- G-protein-coupled receptors (GPCRs) -- work in humans. "They're involved in almost all the biological processes in a human body -- how we perceive light, taste, smell, or how the heart rate is regulated or muscles contract -- and they are targets for over 30% of the drugs that are used today," said Yang Gao, co-first author of the paper and a postdoctoral researcher in the lab of Richard Cerione, the Goldwin Smith Professor of Chemistry and Chemical Biology and co-senior author. The...